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KMID : 1146320170050020118
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Journal of Health Technology Assessment
2017 Volume.5 No. 2 p.118 ~ p.127
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Systematic Review of Diagnostic Accuracy of Fluorodeoxyglucose Positron Emission Tomography for Alzheimer’s Disease
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Kim Ja-Young
Lee Dong-Young
Sohn Chul-Ho
Lee Jun-Young
Son Soo-Kyung
Ryu Young-Hoon
Choi Ji-Eun
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Abstract
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Objectives: It is important to accurately detect individuals with Alzheimer’s disease (AD) to prevent overdiagnosis of the disease. This study aimed to evaluate the diagnostic accuracy of fluorodeoxyglucose positron emission tomography (FDG-PET) in early diagnosis of AD in terms of subcategory of patient.
Methods: Study was approved by the Institutional Review Board of the National Evidence-based Collaborating Agency. We searched relevant articles reported data to determine sensitivity and specificity for AD published until July 2013 from eight electronic database. A bivariate random effect model was used to estimate pooled diagnostic performance.
Results: A total of 5 cross-sectional studies and 13 delayed cross-sectional studies were analyzed. A meta-analysis of
cross-sectional studies resulted in a sensitivity of 0.61 and specificity of 0.81. Delayed cross-sectional studies resulted in a sensitivity of 0.81 and specificity of 0.78. After selecting studies including amnestic mild cognitive impairment (aMCI), there was a higher sensitivity of 0.92 and specificity of 0.88.
Conclusion: FDG-PET may be effective in detecting early stage AD in patients diagnosed with aMCI.
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KEYWORD
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Alzheimer’s disease, FDG-PET, Diagnosis, Accuracy, Systematic review
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